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Mechanotransduction of cardiomyocytes interacting with a thin membrane transducer

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Published 9 May 2007 • 2007 IOP Publishing Ltd
, , Citation Jungyul Park et al 2007 J. Micromech. Microeng. 17 1162 DOI 10.1088/0960-1317/17/6/009

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Author affiliations

1 Biomedical Engineering, Johns Hopkins University, 207 Clark Hall, 3400 N. Charles St., Baltimore, MD 21218, USA

2 School of Mechanical and Aerospace Engineering/Institute of Advanced Machinery and Design, Seoul National University, San 56-1, Sillim-Dong, Gwanak-Gu, Seoul 151-742, Korea

3 Microsystem Research Center, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130-650, Korea

4 School of Mechanical Systems Engineering, Chonnam National University, 300, Youngbong-dong, Buk-gu, Gwangju, 500-757, Korea

5 School of Aerospace & Mechanical Engineering, Hankuk Aviation University, 200-1, Whajon-dong, Deokyang-gu, Koyang-city, Kyonggi-do, 412-791, Korea

Dates

  1. Received 19 January 2007
  2. Published

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Abstract

A novel platform is developed to study the mechanotransduction of cardiomyocytes. After the cardiomyocytes are seeded on 10 µm thin, dome-shaped membranes with different sizes, their morphology and beating frequency are monitored. While the cells seeded on a larger membrane (800 µm × 800 µm) grow normally, cells on a smaller membrane (200 µm × 200 µm) grow in isolated groups, showing a lumped morphology. The beating frequency of the cells on the smaller membrane was faster than on the larger membrane. This intriguing phenomenon may be explained by the mechanical stress determined by the area of the membrane that affects the opening of ion channels.

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10.1088/0960-1317/17/6/009