Quick search Find article
Quick search
Find article

Optimization of nanowire DNA sensor sensitivity using self-consistent simulation

S Baumgartner1, M Vasicek1, A Bulyha1 and C Heitzinger1,2

Show affiliations


In order to facilitate the rational design and the characterization of nanowire field-effect sensors, we have developed a model based on self-consistent charge-transport equations combined with interface conditions for the description of the biofunctionalized surface layer at the semiconductor/electrolyte interface. Crucial processes at the interface, such as the screening of the partial charges of the DNA strands and the influence of the angle of the DNA strands with respect to the nanowire, are computed by a Metropolis Monte Carlo algorithm for charged molecules at interfaces. In order to investigate the sensing mechanism of the device, we have computed the current–voltage characteristics, the electrostatic potential and the concentrations of electrons and holes. Very good agreement with measurements has been found and optimal device parameters have been identified. Our approach provides the capability to study the device sensitivity, which is of fundamental importance for reliable sensing.


PACS

87.85.Qr Nanotechnologies-design

87.15.B- Structure of biomolecules

87.80.-y Biophysical techniques (research methods)

02.70.Uu Applications of Monte Carlo methods

87.14.G- Nucleic acids

07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing

Subjects

Computational physics

Instrumentation and measurement

Medical physics

Biological physics

Dates

Issue 42 (21 October 2011)

Received 13 July 2011, in final form 1 September 2011

Published 26 September 2011



Users also read

What's this?
This innovative new feature generates a list of articles 'also read' by other users based on them reading the original article. Article abstracts citations and references are all considered and weighted accordingly. We hope that this will help you find relevant papers for your research.

  1. Probing the sensitivity of nanowire-based biosensors using liquid-gating
  2. CMOS-compatible fabrication of top-gated field-effect transistor silicon nanowire-based biosensors
  3. Fabrication, characterization and simulation of high performance Si nanowire-based non-volatile memory cells
More

View by subject




Export






Please login to access our web services, or create an account if you don't yet have one.

You must have cookies enabled in your web browser to be able to login.

Username
Password

Forgotten your password? Get a new one here.