Min Zhou et al 2009 Nanotechnology 20 505606 doi:10.1088/0957-4484/20/50/505606
Min Zhou1, Baoxiang Wang, Zbigniew Rozynek, Zhaohui Xie, Jon Otto Fossum, Xiaofeng Yu and Steinar Raaen
Show affiliationsWe describe a rapid environmentally friendly wet-chemical approach to synthesize extremely stable non-toxic, biocompatible, water-soluble monodispersed gold nanoparticles (AuNPs) in one step at room temperature. The particles have been successfully achieved in just a few minutes by merely adding sodium hydroxide (NaOH) acting as an initiator for the reduction of HAuCl4 in aqueous solution in the presence of polyvinylpyrrolidone (PVP) without the use of any reducing agent. It is also proved to be highly efficient for the preparation of AuNPs with controllable sizes. The AuNPs show remarkable stability in water media with high concentrations of salt, various buffer solutions and physiological conditions in biotechnology and biomedicine. Moreover, the AuNPs are also non-toxic at high concentration (100 µM). Therefore, it provides great opportunities to use these AuNPs for biotechnology and biomedicine. This new approach also involved several green chemistry concepts, such as the selection of environmentally benign reagents and solvents, without energy consumption, and less reaction time.
Issue 50 (16 December 2009)
Received 24 August 2009, in final form 29 October 2009
Published 19 November 2009
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