C L Dennis et al 2009 Nanotechnology 20 395103 doi:10.1088/0957-4484/20/39/395103
C L Dennis1,8, A J Jackson2,3, J A Borchers2, P J Hoopes4, R Strawbridge4, A R Foreman5,9, J van Lierop6, C Grüttner7 and R Ivkov5,8,10
Show affiliationsOne potential cancer treatment selectively deposits heat to the tumor through activation of magnetic nanoparticles inside the tumor. This can damage or kill the cancer cells without harming the surrounding healthy tissue. The properties assumed to be most important for this heat generation (saturation magnetization, amplitude and frequency of external magnetic field) originate from theoretical models that assume non-interacting nanoparticles. Although these factors certainly contribute, the fundamental assumption of 'no interaction' is flawed and consequently fails to anticipate their interactions with biological systems and the resulting heat deposition. Experimental evidence demonstrates that for interacting magnetite nanoparticles, determined by their spacing and anisotropy, the resulting collective behavior in the kilohertz frequency regime generates significant heat, leading to nearly complete regression of aggressive mammary tumors in mice.
87.85.Qr Nanotechnologies-design
Issue 39 (30 September 2009)
Received 18 June 2009, in final form 22 July 2009
Published 3 September 2009
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