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Magnetic sensitivity enhanced novel fluorescent magnetic silica nanoparticles for biomedical applications

Jaemoon Yang1, Jaewon Lee1, Jinyoung Kang1,2, Chan-Hwa Chung3, Kwangyeol Lee4, Jin-Suck Suh2,5, Ho-Geun Yoon6, Yong-Min Huh2,5,7 and Seungjoo Haam1,2,7

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We synthesized novel fluorescent magnetic silica nanoparticles (FMSNPs) containing large magnetic components for biomedical application. By employing assemblies of magnetic nanoparticles as kernels against FMSNPs, both the saturation of magnetization and the magnetic resonance (MR) signal intensity were significantly enhanced. Furthermore, the cellular binding of FMSNPs was improved by introducing a positive charge on the surface of the FMSNPs, and fluorescent dyes on the surface of FMSNPs enable optical imaging of sub-cellular regions.


PACS

87.85.Qr Nanotechnologies-design

87.63.L- Visual imaging

87.61.Tg Clinical applications

87.16.-b Subcellular structure and processes

81.16.-c Methods of nanofabrication and processing

Subjects

Biological physics

Medical physics

Nanoscale science and low-D systems

Dates

Issue 7 (20 February 2008)

Received 1 November 2007, in final form 20 December 2007

Published 31 January 2008



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