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Axonal guidance on patterned free-standing nanowire surfaces

Christelle Prinz1, Waldemar Hällström1, Thomas Mårtensson1, Lars Samuelson1, Lars Montelius1 and Martin Kanje2

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We demonstrate high-fidelity guidance of axons using rows of nanowires. The axons are prevented from crossing the rows, making it possible to guide and sort a large number of axons as opposed to when chemical patterns are used. Focal adhesion forms at the nanowires establishing a possible site of information transfer between the surface and the cells. Rows of gallium phosphide (GaP) nanowires were epitaxially grown on GaP(111) substrates in patterns defined by electron beam lithography.


PACS

81.16.Nd Nanolithography

68.35.Np Adhesion

87.85.Qr Nanotechnologies-design

81.16.Rf Nanoscale pattern formation

Subjects

Surfaces, interfaces and thin films

Nanoscale science and low-D systems

Dates

Issue 34 (27 August 2008)

Received 30 May 2008, in final form 24 June 2008

Published 15 July 2008



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