Jason Reed et al 2008 Nanotechnology 19 235101 doi:10.1088/0957-4484/19/23/235101
Jason Reed1,4,6, Matthew Frank2, Joshua J Troke2, Joanna Schmit3, Sen Han3, Michael A Teitell2,4,5,6 and James K Gimzewski1,4,6
Show affiliationsThe dynamic nanomechanical properties of a large number of cells (up to hundreds), measured in parallel with high throughput, are reported. Using NIH 3T3 and HEK 293T fibroblasts and actin depolymerizing drugs, we use a novel nanotechnology to quantify the local viscoelastic properties with applied forces of 20 pN–20 nN, a spatial resolution of <20 nm, and a mechanical dynamic range of several Pa up to ~200 kPa. Our approach utilizes imaging interferometry in combination with reflective, magnetic probes attached to cells. These results indicate that mechanical imaging interferometry is a sensitive and scalable technology for measuring the nanomechanical properties of large arrays of live cells in fluid.
87.85.Qr Nanotechnologies-design
87.19.R- Mechanical and electrical properties of tissues and organs
Issue 23 (11 June 2008)
Received 3 December 2007, in final form 7 February 2008
Published 6 May 2008
Jason Reed et al 2008 Nanotechnology 19 235101
Liping Li et al 2009 Nanotechnology 20 155706
K B Mogensen et al 2009 Nanotechnology 20 095503
Baoli Wang et al 2009 Nanotechnology 20 025603
Paresh Shimpi et al 2009 Nanotechnology 20 125608
I Zardo et al 2009 Nanotechnology 20 155602
H. P. Zhang et al 2009 EPL 87 48011
Michael G Schrlau et al 2008 Nanotechnology 19 015101
Thomas Aref et al 2009 Nanotechnology 20 045303
E R Cintra et al 2009 Nanotechnology 20 045103