Ronald A Schachar et al 2008 Nanotechnology 19 025102 doi:10.1088/0957-4484/19/02/025102
Ronald A Schachar1,3, Wei Chen1, Boon K Woo1, Barbara K Pierscionek2, Xing Zhang1 and Lun Ma1
Show affiliationsThe purpose of this study is to determine the ability of fluorescent nanoparticles to diffuse into a crystalline lens. Intact porcine lenses from five-month-old pigs, intact human lenses obtained from three donors aged 41, 42 and 45 years, and sections of human lens cortex obtained from four donors aged 11, 19, 32, and 34 years were incubated for 72 h at 7 °C in aqueous solutions of green (566 nm) and red (652 nm) fluorescent water soluble cadmium tellurium (CdTe) nanoparticles. As demonstrated by fluorescent and confocal microscopy, the CdTe nanoparticles diffused into the porcine and human lens capsule and into human cortical lens fibres; however, the nanoparticles did not pass through the intact lens capsule. Nanoparticles can be used as a method for studying intracellular structure and biochemical pathways within the lens capsule and cortical lens fibres to further understand cataractogenesis and may serve as a carrier for chemotherapeutic agents for the potential treatment of primary and secondary cataracts.
87.85.Qr Nanotechnologies-design
47.63.mh Transport processes and drug delivery
Issue 2 (16 January 2008)
Received 17 August 2007, in final form 1 November 2007
Published 6 December 2007
Ronald A Schachar et al 2008 Nanotechnology 19 025102
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F L Waelbroeck et al 2009 Plasma Phys. Control. Fusion 51 015015
M H Tsai et al 2009 J. Micromech. Microeng. 19 125021
J E Daw et al 2008 Meas. Sci. Technol. 19 045206
Hanhong Chen et al 2008 Semicond. Sci. Technol. 23 045004
Armand Ajdari and Howard A Stone 2009 New J. Phys. 11 075013
Omid Akhavan and Elham Ghaderi 2009 Sci. Technol. Adv. Mater. 10 015003
M. E. Brown et al 2009 ApJ 706 L110
E. Sergio Santini 2007 EPL 78 30005