Yong-Yong Li et al 2007 Nanotechnology 18 505101 doi:10.1088/0957-4484/18/50/505101
Yong-Yong Li, Xian-Zheng Zhang1, Han Cheng, Jing-Ling Zhu, Un-Nam Li, Si-Xue Cheng and Ren-Xi Zhuo
Show affiliationsAn amphiphilic, biotinylated poly(N-isopropylacrylamide-co-N-(3-dimethylamino propyl)methacrylamide)-block- poly(ε-caprolactone) (biotin-P(NIPAAm-co-NDAPM)- b-PCL) block copolymer was synthesized. The cytotoxicity study showed that the copolymer exhibited no apparent cytotoxicity. In aqueous solution, biotin-P(NIPAAm-co-NDAPM)- b-PCL copolymer was able to self-assemble into micelles of around 60 nm in diameter with a critical micellar concentration (CMC) of 36 mg l−1. Biotin-P(NIPAAm- co-NDAPM)-b-PCL micelles were thermo-responsive and the cloud point temperature was at 36.5 °C. The fluorescent group, fluorescein isothiocyanate (FITC) was further introduced to label the biotin-P(NIPAAm-co-NDAPM)- b-PCL copolymer. A cell internalization experiment was conducted and it was found that the fluorescent micelles could be internalized into the cells. The drug release behavior of drug-loading micelles was also examined and the drug-loaded biotin-P(NIPAAm-co-NDAPM)- b-PCL micelles showed slow drug release at 27 °C and fast drug release at 37 °C.
87.15.N- Properties of solutions of macromolecules
87.15.M- Spectra of biomolecules
Issue 50 (19 December 2007)
Received 29 May 2007, in final form 7 October 2007
Published 20 November 2007
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