Sung-Baek Seo et al 2007 Nanotechnology 18 475105 doi:10.1088/0957-4484/18/47/475105
Sung-Baek Seo1,2, Jaemoon Yang2, Woochan Hyung2, Eun-Jin Cho1,3, Tong-Il Lee4, Yong Jin Song5, Ho-Geun Yoon6, Jin-Suck Suh1,3, Yong-Min Huh1,3,7 and Seungjoo Haam1,2,7
Show affiliationsNovel multifunctional magnetic polycation drug carriers (MPDCs) were synthesized to provide simultaneous magnetically targeted cancer therapy and diagnosis via magnetic resonance imaging (MRI). The MPDCs consist of ultra-sensitive magnetic nanocrystals as MR probes and for magnetic targeting, and a chemotherapeutic agent encapsulated in poly(hexadecylcyanoacrylate) (PHDCA) nanoparticles. The PHDCA nanoparticles were further coated with polycationic polyethylenimine (PEI) to enhance cellular uptake efficiency. The MPDCs demonstrated ultra-sensitivity via MRI and sufficient magnetic mobility under an external magnetic field. Drug loading efficiency and release kinetics were also investigated. From the cell viability data, the MPDCs were nontoxic and the doxorubicin hydrochloride (DOX)-loaded MPDCs exhibited excellent tumorcidal efficacy.
87.85.Qr Nanotechnologies-design
87.61.-c Magnetic resonance imaging
87.80.-y Biophysical techniques (research methods)
Issue 47 (28 November 2007)
Received 25 April 2007, in final form 2 October 2007
Published 26 October 2007
Sung-Baek Seo et al 2007 Nanotechnology 18 475105
A V Soldatov et al 2009 J. Phys.: Conf. Ser. 190 012072
M Pavlinsky et al 1998 Phys. Scr. 1998 33
Daoxin Dai et al 2009 New J. Phys. 11 125016
T Riehm et al 2008 J. Phys.: Conf. Ser. 131 012045
D C Schram et al 2009 J. Phys.: Conf. Ser. 192 012012
B Bhattacharya et al 2007 Nanotechnology 18 485711
F Simon 2008 J. Phys.: Conf. Ser. 110 092029
Sai-Lai Lo and Steve Pope 1999 Distrib. Syst. Engng. 6 13
Thomas L Curtright and Cosmas K Zachos 2002 New J. Phys. 4 83