Yang Liu et al 2007 Nanotechnology 18 424017 doi:10.1088/0957-4484/18/42/424017
Yang Liu1, Shantanu Chakrabartty1 and Evangelyn C Alocilja2
Show affiliationsThis paper describes the fabrication, characterization and modeling of fundamental logic gates that can be used for designing biosensors with embedded forward error-correction (FEC). The proposed logic gates (AND and OR) are constructed by patterning antibodies at different spatial locations along the substrate of a lateral flow immunosensor assay. The logic gates operate by converting binding events between an antigen and an antibody into a measurable electrical signal using polyaniline nanowires as the transducer. In this study, B. cereus and E. coli have been chosen as model pathogens. The functionality of the AND and OR logic gates has been validated using conductance measurements with different pathogen concentrations. Experimental results show that the change in conductance across the gates can be modeled as a log-linear response with respect to varying pathogen concentration. Equivalent circuits models for AND and OR logic gates have been derived based on measured results.
87.85.Qr Nanotechnologies-design
87.80.-y Biophysical techniques (research methods)
Issue 42 (24 October 2007)
Received 3 April 2007, in final form 14 July 2007
Published 19 September 2007
Yang Liu et al 2007 Nanotechnology 18 424017
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