Changqing Yi et al 2007 Nanotechnology 18 025102 doi:10.1088/0957-4484/18/2/025102
Changqing Yi1, Chi-Chun Fong1, Weiwei Chen2, Suijian Qi1, Chi-Hung Tzang1, Shuit-Tong Lee2,3 and Mengsu Yang1,3
Show affiliationsEffects of multi-walled carbon nanotubes (MWCNT) and single-walled carbon nanotubes (SWCNT) functionalized with and without carboxylic groups on polymerase chain reaction (PCR) and restriction digestion reaction were investigated. The results showed that CNT can reduce and even inhibit PCR and restriction digestion reaction, possibly due to the decrease of respective enzyme activity. The inhibition effect on double restriction digestion reaction and PCR was increased in the order of CNT–COOH > pristine CNT and SWCNT> MWCNT. This study demonstrated that CNT may significantly affect the efficiency of biochemical reactions through different action mechanisms, which is critical for understanding how nanomaterials impact biological systems.
87.85.Qr Nanotechnologies-design
Issue 2 (17 January 2007)
Received 14 September 2006, in final form 6 November 2006
Published 15 December 2006
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