Danny N Axford and Jason J Davis 2007 Nanotechnology 18 145502 doi:10.1088/0957-4484/18/14/145502
Danny N Axford and Jason J Davis
Show affiliationsConductive probe atomic force microscopy (CP-AFM) has been used to investigate electronic transport through the protein ferritin in both its holo and apo forms. The presence of the iron oxide core has a notable effect on both conductance and the molecular response to probe-induced compression. This response can also be contrasted with that of the much smaller metalloprotein cytochrome c, across which electron transport can be simulated by a single non-resonant tunnel barrier model. Tapping mode AFM imaging, in different compressional regimes, reveals both the mineral core of holoferritin and significant collapse of the hollow protein cavity of apoferritin. These topographic findings correlate well with CP-AFM conductance data and facilitate a clearer description of electron transport across these molecules.
87.64.Dz Scanning tunneling and atomic force microscopy
82.39.Jn Charge (electron, proton) transfer in biological systems
Issue 14 (11 April 2007)
Received 1 December 2006, in final form 29 January 2007
Published 6 March 2007
Danny N Axford and Jason J Davis 2007 Nanotechnology 18 145502
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