Constantin Pistol and Chris Dwyer 2007 Nanotechnology 18 125305 doi:10.1088/0957-4484/18/12/125305
Constantin Pistol1 and Chris Dwyer2
Show affiliationsWe demonstrate a method for the assembly of fully programmable, large molecular weight DNA complexes. The method leverages sticky-end re-use in a hierarchical fashion to reduce the cost of fabrication by building larger complexes from smaller precursors. We have explored the use of controlled non-specific and specific binding between sticky-ends and demonstrate their use in hierarchical assembly. We conclude that it is feasible to scale this method beyond our demonstration of a fully programmable 8960 kD molecular weight 8 × 8 DNA grid for potential application to complex nanoscale system fabrication.
87.85.Qr Nanotechnologies-design
87.15.A- Theory, modeling, and computer simulation
36.20.Cw Molecular weights, dispersity
Issue 12 (28 March 2007)
Received 30 November 2006, in final form 25 January 2007
Published 23 February 2007
Constantin Pistol and Chris Dwyer 2007 Nanotechnology 18 125305