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Scalable, low-cost, hierarchical assembly of programmable DNA nanostructures

Constantin Pistol1 and Chris Dwyer2

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We demonstrate a method for the assembly of fully programmable, large molecular weight DNA complexes. The method leverages sticky-end re-use in a hierarchical fashion to reduce the cost of fabrication by building larger complexes from smaller precursors. We have explored the use of controlled non-specific and specific binding between sticky-ends and demonstrate their use in hierarchical assembly. We conclude that it is feasible to scale this method beyond our demonstration of a fully programmable 8960 kD molecular weight 8 × 8 DNA grid for potential application to complex nanoscale system fabrication.


PACS

87.85.Qr Nanotechnologies-design

87.15.A- Theory, modeling, and computer simulation

36.20.Cw Molecular weights, dispersity

87.14.G- Nucleic acids

87.15.B- Structure of biomolecules

81.16.Dn Self-assembly

Subjects

Soft matter, liquids and polymers

Atomic and molecular physics

Biological physics

Nanoscale science and low-D systems

Dates

Issue 12 (28 March 2007)

Received 30 November 2006, in final form 25 January 2007

Published 23 February 2007



  1. Scalable, low-cost, hierarchical assembly of programmable DNA nanostructures

    Constantin Pistol and Chris Dwyer 2007 Nanotechnology 18 125305

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