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Gold-coated iron nanoparticles: a novel magnetic resonance agent for T1 and T2 weighted imaging

Sung-Jin Cho1, Benjamin R Jarrett2, Angelique Y Louie2,3 and Susan M Kauzlarich1,3

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Core/shell structured iron(Fe)/gold(Au) nanoparticles have been prepared by a reverse micelle method, and their potential application as magnetic resonance (MR) contrast agent investigated. The average nanoparticle size is 19 nm, as determined by x-ray powder diffraction (XRD) and transmission electron microscopy (TEM). Magnetic properties and relaxivities of nanoparticles are presented and compared. The saturation magnetization is 81 emu g−1 Fe for freshly prepared nanoparticles and the particles have high r1(6.87 mM−1 s−1) when the Fe core is kept from oxidation. These nanoparticles may be used as T1 agents in the unoxidized form.


PACS

61.46.Df Structure of nanocrystals and nanoparticles ("colloidal" quantum dots but not gate-isolated embedded quantum dots)

75.50.Tt Fine-particle systems; nanocrystalline materials

61.05.cp X-ray diffraction

75.30.Cr Saturation moments and magnetic susceptibilities

75.60.Ej Magnetization curves, hysteresis, Barkhausen and related effects

76.60.Es Relaxation effects

Subjects

Condensed matter: electrical, magnetic and optical

Nanoscale science and low-D systems

Dates

Issue 3 (14 February 2006)

Received 9 August 2005, in final form 21 November 2005

Published 6 January 2006



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