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Nanostructured TiO2 thin films as porous cellular interfaces

Abu Samah Zuruzi1,3, Blaine C Butler2, Noel C MacDonald1 and Cyrus R Safinya2

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We report the use of nanostructured TiO2 (NST) as porous cellular adhesion interfaces for microsystems. Integrated NST films and pad arrays with sponge-like morphology were fabricated by aqueous oxidation of Ti films followed by thermal annealing. Cell culture studies indicate significantly (t<0.02 from the student's t-test) greater initial attachment of mouse fibroblast cells on porous NST than on silicon dioxide and nitride films for up to 18 h seeding time. Fibroblasts seeded on NST have flat morphology with numerous processes attaching to walls of NST. These results indicate the potential of using NST as porous cell adhesion films and membranes for bioMEMS applications.


PACS

85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

81.16.Fg Supramolecular and biochemical assembly

68.55.A- Nucleation and growth

68.35.Np Adhesion

68.65.Ac Multilayers

81.40.Ef Cold working, work hardening; annealing, post-deformation annealing, quenching, tempering recovery, and crystallization

81.16.Pr Nanooxidation

Subjects

Electronics and devices

Surfaces, interfaces and thin films

Condensed matter: structural, mechanical & thermal

Nanoscale science and low-D systems

Dates

Issue 2 (28 January 2006)

Received 9 October 2005

Published 21 December 2005



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