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Multi-component nanorods for vaccination applications

A K Salem1,5, C F Hung2, T W Kim2, T C Wu2, P C Searson3 and K W Leong4

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Immune responses from Au/Ni nanorods prepared by electrochemical deposition in alumina templates are evaluated in C57BL/6 mice. When the nanorods are bombarded into skin, they generate a strong CD8 T-cell and antibody response. When pcDNA3 is bound to the Ni segment of the nanorod, it provides a strong immunostimulatory adjuvant effect to the antigen bound on the Au segment.


PACS

87.85.Qr Nanotechnologies-design

87.14.G- Nucleic acids

87.80.-y Biophysical techniques (research methods)

87.16.-b Subcellular structure and processes

Subjects

Instrumentation and measurement

Medical physics

Biological physics

Dates

Issue 4 (April 2005)

Received 8 July 2004, in final form 17 November 2004

Published 11 February 2005



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