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Positive pressure infusion of fluorescent nanoparticles as a probe of the structure of brain phantom gelatins

G T Gillies1,2, S W Allison3 and B M Tissue4

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Positive pressure infusion of Y2O3:Eu3+ particles 8-12 nm in size was carried out in 75 cm3 samples of 0.6% agarose gels that have internal mass transport properties similar to those of in vivo mammalian brain tissue. The purpose of the study was to investigate the nature of the porous-like structure of the gels at distance scales of the order of ≈10 nm. Fluorescence of the particles under UV excitation was used to observe their time-dependent distribution pattern, with the result that the convection-enhanced flow provided by the infusion process caused the particles to permeate the gel's interstitial structure, thus revealing a porosity scale size commensurate with that of the particle size.


PACS

87.85.Qr Nanotechnologies-design

81.05.Rm Porous materials; granular materials

87.85.J- Biomaterials

78.55.Mb Porous materials

Subjects

Condensed matter: electrical, magnetic and optical

Condensed matter: structural, mechanical & thermal

Dates

Issue 4 (August 2002)

Received 21 February 2002

Published 21 June 2002



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