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Continuous real-time bubble monitoring in microchannels using refractive index detection

Shee-Ann Leung, Joshua B Edel, Robert C R Wootton and Andrew J deMello

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A novel approach to the monitoring and analysis of bubbles in gas/liquid binary systems is described. The method is based on the varying extent of refraction experienced by radiation as it passes through a gas or liquid. Specifically, carbonated liquids are hydrodynamically motivated through a microfluidic channel network (40 µm wide and 30 µm deep) and directed through the path of laser beam. As a gas bubble passes through this region, the reduction in local refractive index leads to an increased displacement of the laser beam which is monitored using a position-sensitive detector. Statistical analysis of multiple bubble events (in terms of autocorrelation curves, burst width distributions and interburst time curves) yields information relating to both the bubble size and the frequency of bubble formation.


PACS

47.85.Np Fluidics

85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

47.85.Dh Hydrodynamics, hydraulics, hydrostatics

07.60.Hv Refractometers and reflectometers

47.55.D- Drops and bubbles

06.30.Bp Spatial dimensions (e.g., position, lengths, volume, angles, and displacements)

Subjects

Fluid dynamics

Electronics and devices

Instrumentation and measurement

Nanoscale science and low-D systems

Dates

Issue 1 (January 2004)

Received 20 August 2003, accepted for publication 12 November 2003, in final form 29 October 2003

Published 28 November 2003



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