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Measurement Science and Technology

The characterization of human compact bone structure changes by low-field nuclear magnetic resonance

Author

Qingwen Ni 1,3, J Derwin King 1 and Xiaodu Wang 2

Affiliations

1 Southwest Research Institute, San Antonio, TX 78238, USA
2 Department of Mechanical Engineering and Biomechanics, University of Texas, San Antonio, TX 78249, USA
3 Address for correspondence: Department of Mathematics and Physical Sciences, Texas A&M International University, Laredo, TX 78041, USA

E-mail

qni@tamiu.edu

Journal

Measurement Science and Technology Create an alert RSS this journal

Issue

Volume 15, Number 1

Citation

Qingwen Ni et al 2004 Meas. Sci. Technol. 15 58

doi: 10.1088/0957-0233/15/1/009


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Abstract

A technique of low-field pulsed proton nuclear magnetic resonance (NMR) spin relaxation is described for characterizing the porosity and (effective) pore size distribution in vitro in human compact bone. The technique involves spin–spin relaxation measurement and inversion spin–spin relaxation spectral analysis methods. The spin–spin relaxation decay curve is converted into a T2 distribution spectrum by a sum of single exponential decays. The advantages of using low-field NMR for the spin–spin relaxation technique are illustrated. The results obtained from NMR methodology are compared with the results obtained from currently available but destructive histomorphometry and mercury porosimetry methods. The NMR porosities correlate well with the results obtained from the histomorphometry measurements of eight samples from donors of ages 21–89 years. The pore size distributions from T2 relaxation measurements are similar to the distributions obtained from the mercury porosimetry and histomorphometry measurements. This indicates that the age-related porosity and pore size changes in human compact bone can be detected using the low-field NMR technique.

 
PACS

87.19.R- Mechanical and electrical properties of tissues and organs

87.64.K- Spectroscopy

Subjects

Medical physics

Biological physics

Dates

Issue 1 (January 2004)

Received 6 December 2002 , accepted for publication 2 October 2003 in final form 17 September 2003

Published 20 October 2003



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