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The local atomic structure of di-alanine amino acid derivative of protoporphyrin IX

M S Walczak1, K Lawniczak-Jablonska1, A Sienkiewicz1, M Czuba2, M Klepka1 and A Graczyk2

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The photophysical and photochemical properties of photosensitizers bearing potential for photodynamic diagnosis (PDD) and treatment (PDT) of malignant tissues strictly depend on the details of their chemical processing. In this work, the x-ray absorption spectroscopy (XAFS) and electron spin resonance (ESR) techniques were applied to determine the nearest neighbourhood of iron in the di-alanine amino acid derivative of protoporphyrin IX (L-alanine diprotoporphyrinate). The investigated compound is a technological precursor for novel-class, highly water-soluble protoporphyrin IX-based photosensitizers, which have potential for applications in PDD and PDT and have just entered phase I clinical trials. Knowing the chemical content and exact atomic structures of the technological precursor, as well as of the high-purity final product, which all might contain some contamination, is a prerequisite for preparing photosensitizers for preliminary clinical tests.


PACS

87.50.wp Therapeutic applications

87.19.X- Diseases

87.14.E- Proteins

87.15.B- Structure of biomolecules

36.20.Kd Electronic structure and spectra

Subjects

Soft matter, liquids and polymers

Atomic and molecular physics

Medical physics

Biological physics

Dates

Issue 28 (18 July 2007)

Received 15 October 2006, in final form 22 December 2006

Published 25 June 2007



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