Ole G Mouritsen et al 2006 J. Phys.: Condens. Matter 18 S1293 doi:10.1088/0953-8984/18/28/S12
Activation of interfacial enzymes at membrane surfaces
Ole G Mouritsen1,7, Thomas L Andresen2, Avi Halperin3, Per Lyngs Hansen1, Ask F Jakobsen1,4, Uffe Bernchou Jensen1, Morten Ø Jensen1, Kent Jørgensen2, Thomas Kaasgaard5, Chad Leidy5,6, Adam Cohen Simonsen1, Günther H Peters5 and Matthias Weiss4
Show affiliationsA host of water-soluble enzymes are active at membrane surfaces and in association with membranes. Some of these enzymes are involved in signalling and in modification and remodelling of the membranes. A special class of enzymes, the phospholipases, and in particular secretory phospholipase A2 (sPLA2), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids. The activation is critically dependent on the physical properties of the lipid-membrane substrate. A topical review is given of our current understanding of the physical mechanisms responsible for activation of sPLA2 as derived from a range of different experimental and theoretical investigations.
- PACS
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87.16.D- Membranes, bilayers, and vesicles
87.15.R- Reactions and kinetics
- Subjects
- Dates
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Issue 28 (19 July 2006)
Received 3 November 2005, in final form 1 February 2006
Published 28 June 2006
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Activation of interfacial enzymes at membrane surfaces
Ole G Mouritsen et al 2006 J. Phys.: Condens. Matter 18 S1293
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