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The biological significance of lipid–protein interactions

Heather E Findlay1 and Paula J Booth

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Biological membranes are complex environments, where membrane proteins are surrounded by a bilayer composed of many different types of lipid. The physical properties of the bilayer influence protein structure, folding and function, while specific interactions with lipid molecules can also contribute towards the biological activity of some membrane proteins. Improving understanding of these interactions has resulted in the development of synthetic lipid systems that allow the bilayer properties to be rationally manipulated in vitro to control protein behaviour.


PACS

87.14.Cc Lipids

87.15.B- Structure of biomolecules

87.14.E- Proteins

87.15.K- Molecular interactions; membrane-protein interactions

87.16.D- Membranes, bilayers, and vesicles

Subjects

Biological physics

Dates

Issue 28 (19 July 2006)

Received 3 January 2006, in final form 24 April 2006

Published 28 June 2006



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