Quick search Find article
Quick search
Find article

Proteins as nano-machines: dynamics–function relations studied by neutron scattering

Giuseppe Zaccai1

Show affiliations


A protein is a nano-machine whose molecular structure was selected by evolution to perform specific biological functions. Neutron spectroscopy is uniquely suited to provide experimental data on atomic motions in a protein under the influence of forces that maintain its stable and active molecular structure. Experiments are reviewed relating such a dynamics to soluble protein folding and stability in different environments, and to the activity of bacteriorhodopsin, a membrane protein nano-machine with light-driven proton pump activity.


PACS

87.14.E- Proteins

87.15.B- Structure of biomolecules

87.80.-y Biophysical techniques (research methods)

87.15.H- Dynamics of biomolecules

87.15.Cc Folding: thermodynamics, statistical mechanics, models, and pathways

87.23.Kg Dynamics of evolution

Subjects

Instrumentation and measurement

Medical physics

Biological physics

Environmental and Earth science

Dates

Issue 18 (14 May 2003)

Received 16 October 2002

Published 28 April 2003



  1. Proteins as nano-machines: dynamics–function relations studied by neutron scattering

    Giuseppe Zaccai 2003 J. Phys.: Condens. Matter 15 S1673

  2. Theory of inelastic x-ray scattering from condensed matter

    Sunil K Sinha 2001 J. Phys.: Condens. Matter 13 7511

  3. Brownian motion using video capture

    Reese Salmon et al 2002 Eur. J. Phys. 23 249

  4. Stationary solutions to the nonlinear Schrödinger equation in the presence of third-order dispersion

    Avner Peleg and Yeojin Chung 2003 J. Phys. A: Math. Gen. 36 10039

  5. A high-sensitivity small animal SPECT system

    Gregory S Mitchell and Simon R Cherry 2009 Phys. Med. Biol. 54 1291

  6. Benchmark of PENELOPE code for low-energy photon transport: dose comparisons with MCNP4 and EGS4

    Sung-Joon Ye et al 2004 Phys. Med. Biol. 49 387

  7. The pseudogap in high-temperature superconductors: an experimental survey

    Tom Timusk and Bryan Statt 1999 Rep. Prog. Phys. 62 61

  8. Strongly non-Gaussian statistics of optical soliton parameters due to collisions in the presence of delayed Raman response

    Yeojin Chung and Avner Peleg 2005 Nonlinearity 18 1555

  9. Swift pointing and gravitational-wave bursts from gamma-ray burst events

    Patrick J Sutton et al 2003 Class. Quantum Grav. 20 S815

  10. An ultracool Star's Candidate Planet

    Steven H. Pravdo and Stuart B. Shaklan 2009 ApJ 700 623

View by subject




Export








Please login to access our web services, or create an account if you don't yet have one.

You must have cookies enabled in your web browser to be able to login.

Username
Password

Forgotten your password? Get a new one here.