Marco J P Brugmans et al 2002 J. Radiol. Prot. 22 A75 doi:10.1088/0952-4746/22/3A/314
Marco J P Brugmans1, Harmen Bijwaard and Henk P Leenhouts
Show affiliationsIt is argued that the `cellular' dose-response relationships of model parameters cannot be determined from mechanistic model fits to experimental or epidemiologic cancer data. Baseline population cancer incidence data show conclusions about intermediate cell kinetics to be especially questionable. Here we recommend that mechanistic models should be applied solely in one direction: by starting from known cellular dose-response relationships the models aim at providing a biologically motivated consistent description of the development of radiation-induced cancer for different exposures, which is very important for low-dose risk estimation.
87.50.-a Effects of electromagnetic and acoustic fields on biological systems
Issue 3A (September 2002)
Received 17 February 2002
Published 4 September 2002
Marco J P Brugmans et al 2002 J. Radiol. Prot. 22 A75
H P Leenhouts et al 2002 J. Radiol. Prot. 22 A163
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