H Bijwaard et al 2002 J. Radiol. Prot. 22 A67 doi:10.1088/0952-4746/22/3A/312
H Bijwaard, M J P Brugmans and H P Leenhouts
Show affiliationsA two-mutation carcinogenesis model has been applied to model osteosarcoma incidence in two data sets of beagles injected with 226Ra. Taking age-specific retention into account, the following results have been obtained: (1) a consistent and well-fitting solution for all age and dose groups, (2) mutation rates that are linearly dependent on dose rate, with an exponential decrease for the second mutation at high dose rates, (3) a linear-quadratic dose-effect relationship, which indicates that care should be taken when extrapolating linearly, (4) highest cumulative incidences for injection at young adult age, and highest risks for injection doses of a few kBq kg-1 at these ages, and (5) when scaled appropriately, the beagle model compares fairly well with a description for radium dial painters, suggesting that a consistent model description of bone cancer induction in beagles and humans may be possible.
Issue 3A (September 2002)
Received 17 February 2002
Published 4 September 2002
H Bijwaard et al 2002 J. Radiol. Prot. 22 A67
B J Dabrowska-Wüster et al 2009 New J. Phys. 11 053017
Alexander Moroz and Charles Sommers 1999 J. Phys.: Condens. Matter 11 997
K Trivedi et al 2009 Nanotechnology 20 405204
2001 ApJ 546 605
R Combescot 2003 New J. Phys. 5 86
S Barabash and D Stroud 1999 J. Phys.: Condens. Matter 11 10323
E. W. Thommes et al. 2002 The Astronomical Journal 123 2862
Daniel Torrent and José Sánchez-Dehesa 2008 New J. Phys. 10 023004
Eun-Uk Kim et al 2009 Nanotechnology 20 355302