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Precise measurement of diffusion by multi-color dual-focus fluorescence correlation spectroscopy

C. B. Müller1, A. Loman2, V. Pacheco3, F. Koberling4, D. Willbold3, W. Richtering1 and J. Enderlein2

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Dual-focus fluorescence correlation spectroscopy is a method for precisely measuring the diffusion coefficient of fluorescing molecules close to the infinite dilution limit in a reference-free and absolute manner. We apply the method to determine the diffusion coefficients of three fluorescent dyes across the visible spectrum. These values can be used as absolute reference standards for fluorescence correlation spectroscopy. In particular, it is found that the diffusion coefficient of the widely used reference dye Rhodamine 6G is by 37% larger than the value used in most publications on fluorescence correlation spectroscopy over the last three decades.


PACS

66.10.C- Diffusion and thermal diffusion

87.64.kv Fluorescence

87.15.Vv Diffusion

Subjects

Soft matter, liquids and polymers

Medical physics

Biological physics

Dates

Issue 4 (August 2008)

Received 14 April 2008, accepted for publication 25 June 2008

Published 4 August 2008



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