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On the non-uniqueness of the inverse problem associated with electroencephalography

G Dassios and D Hadjiloizi1

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We present here a quantitative characterization of the non-uniqueness for the inverse problem of electroencephalography (EEG). First, we identify the singular support of the electric potential generated by a dipolar current which is fired inside the spherical model of the brain. Next, we extend this result to a continuously distributed neuronal current and we derive the equivalent Green's integral representation. Then, using the Hansen representation of the current, we show that among the three scalar representation functions, only two are needed to represent the observed electric potential on the surface or outside the head. The scalar function that is missed by the EEG recordings is exactly the one that is recorded by magnetoencephalography (MEG). Finally, the solution of the inverse EEG problem is reduced to a specific moment problem, which is exactly solved under the minimum-current assumption.


PACS

87.19.R- Mechanical and electrical properties of tissues and organs

87.80.-y Biophysical techniques (research methods)

87.19.L- Neuroscience

MSC

26B20 Integral formulas (Stokes, Gauss, Green, etc.)

92C20 Neural biology

92B05 General biology and biomathematics

35R30 Inverse problems (undetermined coefficients, etc.) for PDE

92C50 Medical applications (general)

Subjects

Instrumentation and measurement

Medical physics

Biological physics

Dates

Issue 11 (November 2009)

Received 22 September 2008, in final form 9 September 2009

Published 29 October 2009



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