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Cortical mapping by Laplace–Cauchy transmission using a boundary element method

Maureen Clerc1 and Jan Kybic2

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The Laplace–Cauchy problem of propagating Dirichlet and Neumann data from a portion to the rest of the boundary is an ill-posed inverse problem. Many regularizing algorithms have been recently proposed, in order to stabilize the solution with respect to noisy or incomplete data. Our main application is in electro-encephalography (EEG) where potential measurements available at part of the scalp are used to reconstruct the potential and the current on the inner skull surface. This problem, known as cortical mapping, and other applications—in fields such as nondestructive testing, or biomedical engineering—require us to solve the problem in realistic, three-dimensional geometry. The goal of this paper is to present a new boundary-element-based method for solving the Laplace–Cauchy problem in three dimensions, in a multilayer geometry. We validate the method experimentally on simulated data.


PACS

87.85.Ng Biological signal processing

87.19.R- Mechanical and electrical properties of tissues and organs

87.19.L- Neuroscience

02.30.Zz Inverse problems

02.60.Lj Ordinary and partial differential equations; boundary value problems

MSC

92C20 Neural biology

65N38 Boundary element methods

92C55 Biomedical imaging and signal processing (See also 44A12, 65R10)

65F22 Ill-posedness, regularization

Subjects

Mathematical physics

Computational physics

Medical physics

Biological physics

Dates

Issue 6 (December 2007)

Received 30 May 2007, in final form 28 September 2007

Published 23 November 2007



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