Zhang Ning et al 2009 Chinese Phys. Lett. 26 110501 doi:10.1088/0256-307X/26/11/110501
Stochastic Alternating Dynamics for Synchronous EAD-Like Beating Rhythms in Cultured Cardiac Myocytes
Zhang Ning, Zhang Hui-Min, Liu Zhi-Qiang, Ding Xue-Li, Yang Ming-Hao, Gu Hua-Guang and Ren Wei
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Dissolved cardiac myocytes can couple together and generate synchronous beatings in culture. We observed a synchronized early after-depolarization(EAD)-like rhythm in cultured cardiac myocytes and reproduced the experimental observation in a network mathematical model whose dynamics are close to a Hopf bifurcation. The mechanism for this EAD-like rhythm is attributed to noised-induced stochastic alternatings between the focus and the limit cycle. These results provide novel understandings for pathological heart rhythms like the early immature beatings.
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Issue 11 (November 2009)
Received 8 July 2009
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Stochastic Alternating Dynamics for Synchronous EAD-Like Beating Rhythms in Cultured Cardiac Myocytes
Zhang Ning et al 2009 Chinese Phys. Lett. 26 110501
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