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Monte Carlo Simulation of Kinesin Movement with a Lattice Model

Wang Hong, Dou Shuo-Xing and Wang Peng-Ye

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Kinesin is a processive double-headed molecular motor that moves along a microtubule by taking about 8 nm steps. It generally hydrolyzes one ATP molecule for taking each forward step. The processive movement of the kinesin molecular motors is numerically simulated with a lattice model. The motors are considered as Brownian particles and the ATPase processes of both heads are taken into account. The Monte Carlo simulation results agree well with recent experimental observations, especially on the relation of velocity versus ATP and ADP concentrations.


PACS

87.17.Jj Cell locomotion, chemotaxis

87.16.Ka Filaments, microtubules, their networks, and supramolecular assemblies

02.70.Uu Applications of Monte Carlo methods

87.16.Nn Motor proteins (myosin, kinesin dynein)

87.17.Aa Modeling, computer simulation of cell processes

87.15.R- Reactions and kinetics

Subjects

Computational physics

Biological physics

Dates

Issue 11 (November 2005)

Received 30 June 2005



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