Beau A Standish et al 2010 Phys. Med. Biol. 55 615 doi:10.1088/0031-9155/55/3/004
Beau A Standish1, Kenneth K C Lee2, Adrian Mariampillai1, Nigel R Munce1, Michael K K Leung1, Victor X D Yang2,3,4 and I Alex Vitkin1,2,5
Show affiliationsA multichannel optical coherence tomography (multi-beam OCT) system and an in vivo endoscopic imaging probe were developed using a swept-source OCT system. The distal optics were micro-machined to produce a high numerical aperture, multi-focus fibre optic array. This combination resulted in a transverse design resolution of <10 µm full width half maximum (FWHM) throughout the entire imaging range, while also increasing the signal intensity within the focus of the individual channels. The system was used in a pre-clinical rabbit study to acquire in vivo structural images of the colon and ex vivo images of the oesophagus and trachea. A good correlation between the structural multi-beam OCT images and H&E histology was achieved, demonstrating the feasibility of this high-resolution system and its potential for in vivo human endoscopic imaging.
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Issue 3 (7 February 2010)
Received 2 June 2009, in final form 12 November 2009
Published 13 January 2010
Beau A Standish et al 2010 Phys. Med. Biol. 55 615
P Mansfield and P K Grannell 1973 J. Phys. C: Solid State Phys. 6 L422
S Westwood et al 2009 Metrologia 46 08019
Kyung Joong Kim 2009 Metrologia 46 08006
Joële Viallon et al 2006 Metrologia 43 08010
Jascindra Ravi et al 2010 Metrologia 47 08022
Robert B Jackson et al 2008 Environ. Res. Lett. 3 044006
Sarah R Cooley and Scott C Doney 2009 Environ. Res. Lett. 4 024007
1997 Nanotechnology 8 A1
Emanuele Berti et al 2009 Class. Quantum Grav. 26 163001