Beau A Standish et al 2010 Phys. Med. Biol. 55 615 doi:10.1088/0031-9155/55/3/004
Beau A Standish1, Kenneth K C Lee2, Adrian Mariampillai1, Nigel R Munce1, Michael K K Leung1, Victor X D Yang2,3,4 and I Alex Vitkin1,2,5
Show affiliationsA multichannel optical coherence tomography (multi-beam OCT) system and an in vivo endoscopic imaging probe were developed using a swept-source OCT system. The distal optics were micro-machined to produce a high numerical aperture, multi-focus fibre optic array. This combination resulted in a transverse design resolution of <10 µm full width half maximum (FWHM) throughout the entire imaging range, while also increasing the signal intensity within the focus of the individual channels. The system was used in a pre-clinical rabbit study to acquire in vivo structural images of the colon and ex vivo images of the oesophagus and trachea. A good correlation between the structural multi-beam OCT images and H&E histology was achieved, demonstrating the feasibility of this high-resolution system and its potential for in vivo human endoscopic imaging.
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Issue 3 (7 February 2010)
Received 2 June 2009, in final form 12 November 2009
Published 13 January 2010
Beau A Standish et al 2010 Phys. Med. Biol. 55 615
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