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Development of a remanence measurement-based SQUID system with in-depth resolution for nanoparticle imaging

Song Ge1,2, Xiangyang Shi2,4, James R Baker Jr2, Mark M Banaszak Holl2,3 and Bradford G Orr1,2,4

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We present a remanence measurement method using a superconducting quantum interference device (SQUID) to detect trace amounts of magnetic nanoparticles (MNPs). Based on this method, a one-dimensional scanning system was established for imaging. The system was calibrated with 25 nm diameter Fe2O3 nanoparticles (NPs), and the sensitivity of the NPs was found to be 10 ng at a distance of 1.7 cm and the spatial resolution was ~1 cm. A theoretical model of this system was developed and applied to the deconvolution of scanned images of phantoms with two NP injection spots. Using the developed SQUID system, we were able to determine not only the amount and horizontal positions of the injections, but also their depths in the phantoms.


PACS

87.85.Qr Nanotechnologies-design

87.57.C- Image quality

07.55.Ge Magnetometers for magnetic field measurements

87.56.Da Ancillary equipment

85.25.Dq Superconducting quantum interference devices (SQUIDs)

Subjects

Superconductivity

Instrumentation and measurement

Medical physics

Dates

Issue 10 (21 May 2009)

Received 9 February 2009, in final form 20 March 2009

Published 27 April 2009



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