Yoshihito Hayashi et al 2008 Phys. Med. Biol. 53 295 doi:10.1088/0031-9155/53/1/021
Yoshihito Hayashi1, Ikuya Oshige1, Yoichi Katsumoto1, Shinji Omori1, Akio Yasuda1 and Koji Asami2
Show affiliationsRabbit blood was preserved at 277 K in Alsever's solution for 37 days, and its dielectric permittivity was monitored in a frequency range from 0.05 to 110 MHz throughout the period. The relaxation time and Cole–Cole parameter of the interfacial polarization process for erythrocytes remained nearly constant during the first 20 days and then started to increase and decrease, respectively. On the other hand, the relaxation strength and the cell volume fraction continued to decrease for 37 days, but the decrease rates of both changed discontinuously on about the 20th day. Microscope observation showed that approximately 90% of the erythrocytes were spinous echinocytes at the beginning of preservation and started to be transformed into microspherocytes around the 20th day. Therefore, dielectric spectroscopy is a sensitive tool to monitor the deterioration of preserved blood accompanied by morphological transition of erythrocytes through the temporal variation of their dielectric properties.
87.19.R- Mechanical and electrical properties of tissues and organs
87.64.-t Spectroscopic and microscopic techniques in biophysics and medical physics
Issue 1 (7 January 2008)
Received 28 September 2007, in final form 22 November 2007
Published 19 December 2007
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