John C Roeske and Mark Hoggarth 2007 Phys. Med. Biol. 52 1909 doi:10.1088/0031-9155/52/7/010
John C Roeske1 and Mark Hoggarth2
Show affiliationsAlpha-particle emitters are currently being evaluated in the treatment of cancer. Because of the short range and high linear energy transfer (LET) of most therapeutic alpha-particle emitters, there are significant stochastic variations in the energy deposited within the cellular nucleus. Hence microdosimetric spectra are often necessary to interpret biological endpoints. However, alpha-particle microdosimetric codes are not readily available. In this paper, we describe how a commercial spreadsheet may be used to perform a Monte Carlo simulation of alpha-particle transport. Subsequently, this information is used to determine the distribution of path lengths, energy deposited, and specific energy for a single alpha-particle traversal through the cell nucleus. These data may then be used to determine microdosimetric parameters for multiple alpha-particle emissions. In our analysis, comparison of the first and second moments of the single-event spectra with previously published data show agreement on the order of a few per cent. These small discrepancies are due to differences in interpolation of stopping powers between the various algorithms. Thus, the spreadsheet Monte Carlo method represents a simple and efficient method to calculate single-event spectra for alpha-particle emitters. Copies of the spreadsheet are available from the corresponding author upon request.
Issue 7 (7 April 2007)
Received 23 November 2006, in final form 21 December 2006
Published 12 March 2007
John C Roeske and Mark Hoggarth 2007 Phys. Med. Biol. 52 1909
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