Renzhi Lu et al 2007 Phys. Med. Biol. 52 849 doi:10.1088/0031-9155/52/3/022
Renzhi Lu1, Richard J Radke1, Laura Happersett2, Jie Yang2, Chen-Shou Chui2,3, Ellen Yorke2 and Andrew Jackson2
Show affiliationsIntensity-modulated radiotherapy (IMRT) has become an effective tool for cancer treatment with radiation. However, even expert radiation planners still need to spend a substantial amount of time manually adjusting IMRT optimization parameters such as dose limits and costlet weights in order to obtain a clinically acceptable plan. In this paper, we describe two main advances that simplify the parameter adjustment process for five-field prostate IMRT planning. First, we report the results of a sensitivity analysis that quantifies the effect of each hand-tunable parameter of the IMRT cost function on each clinical objective and the overall quality of the resulting plan. Second, we show that a recursive random search over the six most sensitive parameters as an outer loop in IMRT planning can quickly and automatically determine parameters for the cost function that lead to a plan meeting the clinical requirements. Our experiments on a ten-patient dataset show that for 70% of the cases, we can automatically determine a plan in 10 min (on the average) that is either clinically acceptable or requires only minor adjustment by the planner. The outer-loop optimization can be easily integrated into a traditional IMRT planning system.
For more information on this article, see medicalphysicsweb.org
Issue 3 (7 February 2007)
Received 3 August 2006, in final form 6 November 2006
Published 17 January 2007
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