Christina Skourou et al 2007 Phys. Med. Biol. 52 347 doi:10.1088/0031-9155/52/2/003
Christina Skourou1, Andreas Rohr2, P Jack Hoopes3 and Keith D Paulsen4
Show affiliationsElectrical impedance spectroscopy (EIS) is a non-ionizing, non-invasive technique which can be used to detect the presence of malignant tumours based on their electrical properties. Although it has been suggested that the edema which accompanies tumours strongly influences EIS tumour characterization, such information has not, until now, been documented in the literature. Growing intramuscular rodent tumours were imaged using magnetic resonance imaging (MRI) and EIS at several time points post-tumour implantation. The amount of edema associated with the tumours was calculated from the MRI images. Electrical parameters (resistivity, permittivity, fluid index ratio and peak frequency) were extracted from the EIS spectra. Taken together, the resulting electrical parameters strongly indicate that edema is the dominating pathological feature in EIS characterization and can at times conceal the presence of the tumour. Receiver operating characteristic analysis supports these findings.
87.63.Pn Electrical impedance tomography (EIT)
87.61.-c Magnetic resonance imaging
87.19.R- Mechanical and electrical properties of tissues and organs
Issue 2 (21 January 2007)
Received 19 July 2006, in final form 13 November 2006
Published 21 December 2006
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