E Kanoulas et al 2007 Phys. Med. Biol. 52 5443 doi:10.1088/0031-9155/52/17/023
E Kanoulas1, J A Aslam1, G C Sharp2, R I Berbeco3, S Nishioka4, H Shirato5 and S B Jiang2,6
Show affiliationsIn this work we develop techniques that can derive the tumor position from external respiratory surrogates (abdominal surface motion) through periodically updated internal/external correlation. A simple linear function is used to express the correlation between the tumor and surrogate motion. The function parameters are established during a patient setup session with the tumor and surrogate positions simultaneously measured at a 30 Hz rate. During treatment, the surrogate position, constantly acquired at 30 Hz, is used to derive the tumor position. Occasionally, a pair of radiographic images is acquired to enable the updating of the linear correlation function. Four update methods, two aggressive and two conservative, are investigated: (A1) shift line through the update point; (A2) re-fit line through the update point; (C1) re-fit line with extra weight to the update point; (C2) minimize the distances to the update point and previous line fit point. In the present study of eight lung cancer patients, tumor and external surrogate motion demonstrate a high degree of linear correlation which changes dynamically over time. It was found that occasionally updating the correlation function leads to more accurate predictions than using external surrogates alone. In the case of high imaging rates during treatment (greater than 2 Hz) the aggressive update methods (A1 and A2) are more accurate than the conservative ones (C1 and C2). The opposite is observed in the case of low imaging rates.
Issue 17 (7 September 2007)
Received 9 February 2007, in final form 2 August 2007
Published 21 August 2007
E Kanoulas et al 2007 Phys. Med. Biol. 52 5443
D.-C. Kim et al. 2002 ApJS 143 277
Nathaniel R. Butler et al. 2007 ApJ 671 656
L. Ofman and B. J. Thompson 2002 ApJ 574 440
U. Feldman et al. 1997 ApJS 113 195
R McGrath et al 2010 J. Phys.: Condens. Matter 22 084022
P Sperfeld et al 2000 Metrologia 37 373
Y Jack Ng and H van Dam 2005 J. Phys. A: Math. Gen. 38 L317
Nozomu Kawakatu and Keiichi Wada 2009 ApJ 706 676
Holly K Gibbs et al 2008 Environ. Res. Lett. 3 034001