M J Daniels et al 2007 Phys. Med. Biol. 52 4827 doi:10.1088/0031-9155/52/16/008
M J Daniels1,2, T Varghese1, E L Madsen1 and J A Zagzebski1
Show affiliationsMinimally invasive therapies (such as radiofrequency ablation) are becoming more commonly used in the United States for the treatment of hepatocellular carcinomas and liver metastases. Unfortunately, these procedures suffer from high recurrence rates of hepatocellular carcinoma (~34–55%) or metastases following ablation therapy. The ability to perform real-time temperature imaging while a patient is undergoing radiofrequency ablation could provide a significant reduction in these recurrence rates. In this paper, we demonstrate the feasibility of ultrasound-based temperature imaging on a tissue-mimicking phantom undergoing radiofrequency heating. Ultrasound echo signals undergo time shifts with increasing temperature, which are tracked using 2D correlation-based speckle tracking methods. Time shifts or displacements in the echo signal are accumulated, and the gradient of these time shifts are related to changes in the temperature of the tissue-mimicking phantom material using a calibration curve generated from experimental data. A tissue-mimicking phantom was developed that can undergo repeated radiofrequency heating procedures. Both sound speed and thermal expansion changes of the tissue-mimicking material were measured experimentally and utilized to generate the calibration curve relating temperature to the displacement gradient. Temperature maps were obtained, and specific regions-of-interest on the temperature maps were compared to invasive temperatures obtained using fiber-optic temperature probes at the same location. Temperature elevation during a radiofrequency ablation procedure on the phantom was successfully tracked to within ±0.5 °C.
87.19.Pp Biothermics and thermal processes in biology
Issue 16 (21 August 2007)
Received 28 February 2007, in final form 22 May 2007
Published 30 July 2007
M J Daniels et al 2007 Phys. Med. Biol. 52 4827
Ph Lalanne et al 2000 J. Opt. A: Pure Appl. Opt. 2 48
P Velha et al 2006 New J. Phys. 8 204
H E Lomelí and J D Meiss 2009 Nonlinearity 22 1761
Héctor E Lomelí et al 2008 Nonlinearity 21 485
D R Reynolds et al 2008 J. Phys.: Conf. Ser. 125 012085
David E Keyes et al 2006 J. Phys.: Conf. Ser. 46 433
B. A. Whitney et al. 2008 The Astronomical Journal 136 18
G Massiera et al 2003 J. Phys.: Condens. Matter 15 S225
Murat Durandurdu 2009 J. Phys.: Condens. Matter 21 452204