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Formulating adaptive radiation therapy (ART) treatment planning into a closed-loop control framework*

Adam de la Zerda1, Benjamin Armbruster2 and Lei Xing3

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While ART has been studied for years, the specific quantitative implementation details have not. In order for this new scheme of radiation therapy (RT) to reach its potential, an effective ART treatment planning strategy capable of taking into account the dose delivery history and the patient's on-treatment geometric model must be in place. This paper performs a theoretical study of dynamic closed-loop control algorithms for ART and compares their utility with data from phantom and clinical cases. We developed two classes of algorithms: those Adapting to Changing Geometry and those Adapting to Geometry and Delivered Dose. The former class takes into account organ deformations found just before treatment. The latter class optimizes the dose distribution accumulated over the entire course of treatment by adapting at each fraction, not only to the information just before treatment about organ deformations but also to the dose delivery history. We showcase two algorithms in the class of those Adapting to Geometry and Delivered Dose. A comparison of the approaches indicates that certain closed-loop ART algorithms may significantly improve the current practice. We anticipate that improvements in imaging, dose verification and reporting will further increase the importance of adaptive algorithms.


Footnote
*  Presented at ASTRO Annual Meeting, 2006, Philadelphia, PA.
PACS

87.55.-x Treatment strategy

87.59.bd Computed radiography

02.50.-r Probability theory, stochastic processes, and statistics

87.56.Da Ancillary equipment

07.05.Dz Control systems

Subjects

Computational physics

Instrumentation and measurement

Medical physics

Dates

Issue 14 (21 July 2007)

Received 17 January 2007, in final form 25 April 2007

Published 14 June 2007



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