H C Bryant et al 2007 Phys. Med. Biol. 52 4009 doi:10.1088/0031-9155/52/14/001
H C Bryant1,2, D A Sergatskov1, Debbie Lovato3, Natalie L Adolphi1,4, Richard S Larson3 and Edward R Flynn1,2
Show affiliationsSuperparamagnetic nanoparticles can be attached in great numbers to pathogenic cells using specific antibodies so that the magnetically-labeled cells themselves become superparamagnets. The cells can then be manipulated and drawn out of biological fluids, as in a biopsy, very selectively using a magnetic needle. We examine the origins and uncertainties in the forces exerted on magnetic nanoparticles by static magnetic fields, leading to a model for trajectories and collection times of dilute superparamagnetic cells in biological fluids. We discuss the design and application of such magnetic needles and the theory of collection times. We compare the mathematical model to measurements in a variety of media including blood.
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87.80.-y Biophysical techniques (research methods)
87.50.C- Static and low-frequency electric and magnetic fields effects
Issue 14 (21 July 2007)
Received 19 April 2007, in final form 18 May 2007
Published 8 June 2007
H C Bryant et al 2007 Phys. Med. Biol. 52 4009
M. Rosvall and K. Sneppen 2006 Europhys. Lett. 74 1109
E. Schinnerer et al. 2004 The Astronomical Journal 128 1974
B Szafran et al 2000 J. Phys.: Condens. Matter 12 6837
B Szafran et al 2002 J. Phys.: Condens. Matter 14 73
B Szafran et al 2000 J. Phys.: Condens. Matter 12 2453
A Doliwa et al 2003 J. Phys. A: Math. Gen. 36 4827
Mariusz Białecki and Jonathan J C Nimmo 2007 J. Phys. A: Math. Theor. 40 949
Andrea Alù and Nader Engheta 2009 New J. Phys. 11 013026
Luc Blanchet et al 1996 Class. Quantum Grav. 13 575