Martin Lepage et al 2007 Phys. Med. Biol. 52 N249 doi:10.1088/0031-9155/52/10/N04
Martin Lepage1, Jinqiang Jiang2,3, Jérôme Babin2, Bo Qi2, Luc Tremblay1 and Yue Zhao2
Show affiliationsThe encapsulation of molecules into nanocarriers is studied for its potential in delivering a high dose of anticancer drugs to a tumor, while minimizing side effects. Most systems either release their content in a non-specific manner or under specific environmental conditions such as temperature or pH. We have synthesized a novel class of photo-controllable polymer micelles that can stably encapsulate a hydrophilic compound and subsequently release it upon absorption of UV light. Here, we describe an in vitro magnetic resonance imaging assay that can evaluate the state of incorporation of a small Gd-based contrast agent. Our results indicate that the contrast agent alone can diffuse through a filter, but that the same agent incorporated into micelles cannot. After exposure to UV light, the micelles released the contrast agent, which could then diffuse through the filter.
Issue 10 (21 May 2007)
Received 14 February 2007, in final form 10 April 2007
Published 1 May 2007
Martin Lepage et al 2007 Phys. Med. Biol. 52 N249
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