Quick search Find article
Quick search
Find article

MR guided focused ultrasound: technical acceptance measures for a clinical system

K R Gorny, N J Hangiandreou, G K Hesley, B S Gostout, K P McGee and J P Felmlee

Show affiliations


Magnetic resonance (MR) guided focused ultrasound (MRgFUS) is a hybrid technique which offers efficient and safe focused ultrasound (FUS) treatments of uterine fibroids under MR guidance and monitoring. As a therapy device, MRgFUS requires systematic testing over a wide range of operational parameters prior to use in the clinical environment. We present technical acceptance tests and data for the first clinical MRgFUS system, ExAblate® 2000 (InSightec Inc., Haifa, Israel), that has been FDA approved for treating uterine fibroids. These tests characterize MRgFUS by employing MR temperature measurements in tissue mimicking phantoms. The coronal scan plane is empirically demonstrated to be most reliable for measuring temperature elevations resulting from high intensity ultrasound (US) pulses ('sonications') and shows high sensitivity to changes in sonication parameters. Temperatures measured in the coronal plane were used as a measure of US energy deposited within the focal spot for a range of sonication parameters used in clinical treatments: spot type, spot length, output power, sonication duration, US frequency, and depth of sonication. In addition, MR images acquired during sonications were used to measure effective diameters and lengths of available sonication spot types and lengths. At a constant 60 W output power, the effective spot type diameters were measured to vary between 4.7 ± 0.3 mm and 6.6 ± 0.4 mm; treatment temperatures were found to decrease with increasing spot diameter. Prescribing different spot lengths was found to have no effect on the measured length or on measured temperatures. Tests of MRgFUS positioning accuracy determined errors in the direction parallel to the propagation of the US beam to be significantly greater than those in the perpendicular direction; most sonication spots were erroneously positioned towards the FUS transducer. The tests reported here have been demonstrated to be sufficiently sensitive to detect water leakage inside the FUS transducer. The data presented could be used for comparison by those conducting acceptance tests on other clinical MRgFUS systems.


PACS

87.50.yt Therapeutic applications

43.80.Vj Acoustical medical instrumentation and measurement techniques

87.19.Pp Biothermics and thermal processes in biology

87.61.Tg Clinical applications

Subjects

Medical physics

Biological physics

Dates

Issue 12 (21 June 2006)

Received 4 February 2006, in final form 6 February 2006

Published 6 June 2006



  1. MR guided focused ultrasound: technical acceptance measures for a clinical system

    K R Gorny et al 2006 Phys. Med. Biol. 51 3155

  2. Measurements of Three-dimensional Coronal Magnetic Fields from Coordinated Extreme-Ultraviolet and Radio Observations of a Solar Active Region Sunspot

    Jeffrey W. Brosius et al. 2002 ApJ 574 453

  3. Galaxy Populations and Evolution in Clusters. IV. Deep H I Observations of Dwarf Elliptical Galaxies in the Virgo Cluster

    Christopher J. Conselice et al. 2003 ApJ 591 167

  4. Nano-depth grooves formed through O2 plasma etching in the presence of PTFE

    Nobuo Misawa and Shoji Takeuchi 2009 J. Micromech. Microeng. 19 115032

  5. Tri- and quadri-metallic ultrathin nanowires synthesized by one-step phase-transfer approach

    Wei-Qiang Han et al 2009 Nanotechnology 20 495605

  6. Prompt GeV-TeV Emission of Gamma-Ray Bursts Due to High-Energy Protons, Muons, and Electron-Positron Pairs

    Katsuaki Asano and Susumu Inoue 2007 ApJ 671 645

  7. The Inability of Ambipolar Diffusion to Set a Characteristic Mass Scale in Molecular Clouds

    Jeffrey S. Oishi and Mordecai-Mark Mac Low 2006 ApJ 638 281

  8. Dynamic Fano resonance of Floquet-state excitons in superlattices

    Ren-Bao Liu and Bang-fen Zhu 2000 J. Phys.: Condens. Matter 12 L741

  9. A relationship of mean-field theory for a driven lattice gas to an exact equilibrium density functional

    W S Brams Dwandaru and Matthias Schmidt 2007 J. Phys. A: Math. Theor. 40 13209

  10. Interferometry for the LISA technology package (LTP) aboard SMART-2

    G Heinzel et al 2003 Class. Quantum Grav. 20 S153

View by subject




Export








Please login to access our web services, or create an account if you don't yet have one.

You must have cookies enabled in your web browser to be able to login.

Username
Password

Forgotten your password? Get a new one here.