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Measurement of ion diffusion using magnetic resonance electrical impedance tomography

Mark J Hamamura, L Tugan Muftuler, Ozlem Birgul and Orhan Nalcioglu

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In magnetic resonance electrical impedance tomography (MREIT), currents are applied to an object, the resulting magnetic flux density measured using MRI and the conductivity distribution reconstructed using these MRI data. In this study, we assess the ability of MREIT to monitor changes in the conductivity distribution of an agarose gel phantom, using injected current pulses of 900 µA. The phantom initially contained a distinct region of high sodium chloride concentration which diffused into the background over time. MREIT data were collected over a 12 h span, and conductivity images were reconstructed using the iterative sensitivity matrix method with Tikhonov regularization. The results indicate that MREIT was able to monitor the changing conductivity and concentration distributions resulting from the diffusion of ions within the agarose gel phantom.


PACS

87.63.Pn Electrical impedance tomography (EIT)

87.61.Tg Clinical applications

87.19.R- Mechanical and electrical properties of tissues and organs

87.57.N- Image analysis

Subjects

Biological physics

Medical physics

Dates

Issue 11 (7 June 2006)

Received 9 February 2006, in final form 10 February 2006

Published 9 May 2006



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