Millie Chu et al 2005 Phys. Med. Biol. 50 5463 doi:10.1088/0031-9155/50/23/003
Robust optimization for intensity modulated radiation therapy treatment planning under uncertainty
Millie Chu1, Yuriy Zinchenko1, Shane G Henderson1 and Michael B Sharpe2
Show affiliationsThe recent development of intensity modulated radiation therapy (IMRT) allows the dose distribution to be tailored to match the tumour's shape and position, avoiding damage to healthy tissue to a greater extent than previously possible. Traditional treatment plans assume that the target structure remains in a fixed location throughout treatment. However, many studies have shown that because of organ motion, inconsistencies in patient positioning over the weeks of treatment, etc, the tumour location is not stationary. We present a probabilistic model for the IMRT inverse problem and show that it is identical to using robust optimization techniques, under certain assumptions. For a sample prostate case, our computational results show that this method is computationally feasible and promising—compared to traditional methods, our model has the potential to find treatment plans that are more adept at sparing healthy tissue while maintaining the prescribed dose to the target.
- PACS
- Subjects
- Dates
-
Issue 23 (7 December 2005)
Received 1 June 2005, in final form 29 September 2005
Published 9 November 2005
-
Robust optimization for intensity modulated radiation therapy treatment planning under uncertainty
Millie Chu et al 2005 Phys. Med. Biol. 50 5463
-
Determination of the vectorelectrogram in isolated rat atria: application to the study of arrhythmias
Nivaldo Zafalon et al 2009 Physiol. Meas. 30 1281
-
Zitterbewegung and semiclassical observables for the Dirac equation
Jens Bolte and Rainer Glaser 2004 J. Phys. A: Math. Gen. 37 6359
-
Microstructure and electrical properties of quenched AgPb18Sb1−xTe20 thermoelectric materials
T J Zhu et al 2007 J. Phys. D: Appl. Phys. 40 3537
-
Continuum equations for dielectric response to macro-molecular assemblies at the nano scale
Ridgway Scott et al 2004 J. Phys. A: Math. Gen. 37 9791
-
The standard model and its generalizations in the Epstein-Glaser approach to renormalization theory: II. The fermion sector and the axial anomaly
D R Grigore 2001 J. Phys. A: Math. Gen. 34 5429
-
Low frequency noise in Co/Al2O3
δ(Fe)
/Ni80Fe20 magnetic tunnel junctions
R Guerrero et al 2002 J. Phys. D: Appl. Phys. 35 1761
-
Hidden Markov modelling of spike propagation from interictal MEG data
A Ossadtchi et al 2005 Phys. Med. Biol. 50 3447
-
On two-dimensional fractional Brownian motion and fractional Brownian random field
Hong Qian et al 1998 J. Phys. A: Math. Gen. 31 L527
-
Coherent states for the q-deformed quantum mechanics on a circle
K Kowalski and J Rembieliński 2004 J. Phys. A: Math. Gen. 37 11447