Robert L P van Veen et al 2005 Phys. Med. Biol. 50 2573 doi:10.1088/0031-9155/50/11/009
Robert L P van Veen1, Arjen Amelink1, Marian Menke-Pluymers2, Carmen van der Pol2 and Henricus J C M Sterenborg1
Show affiliationsDifferential path-length spectroscopy (DPS) was used to determine the local optical properties of breast tissue in vivo. DPS measurements were made on healthy and malignant breast tissue using a fibre-optic needle probe, and were correlated to the histological outcome of core-needle biopsies taken from the same location as the measurements. DPS yields information on the local tissue blood content, the local blood oxygenation, the average micro-vessel diameter, the β-carotene concentration and the scatter slope. Our data show that malignant breast tissue is characterized by a significant decrease in tissue oxygenation and a higher blood content compared to normal breast tissue.
Instrumentation and measurement
Issue 11 (7 June 2005)
Received 12 November 2004
Published 18 May 2005
Robert L P van Veen et al 2005 Phys. Med. Biol. 50 2573
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