Peter E Andersen et al 2004 Phys. Med. Biol. 49 1307 doi:10.1088/0031-9155/49/7/017
Peter E Andersen1, Lars Thrane1, Harold T Yura2, Andreas Tycho1, Thomas M Jørgensen1 and Michael H Frosz1,3
Show affiliationsAnalytical and numerical models for describing and understanding the light propagation in samples imaged by optical coherence tomography (OCT) systems are presented. An analytical model for calculating the OCT signal based on the extended Huygens–Fresnel principle valid both for the single and multiple scattering regimes is reviewed. An advanced Monte Carlo model for calculating the OCT signal is also reviewed, and the validity of this model is shown through a mathematical proof based on the extended Huygens–Fresnel principle. Moreover, for the first time the model is verified experimentally. From the analytical model, an algorithm for enhancing OCT images is developed; the so-called true-reflection algorithm in which the OCT signal may be corrected for the attenuation caused by scattering. For the first time, the algorithm is demonstrated by using the Monte Carlo model as a numerical tissue phantom. Such algorithm holds promise for improving OCT imagery and to extend the possibility for functional imaging.
87.50.W- Optical/infrared radiation effects
02.50.Ng Distribution theory and Monte Carlo studies
Issue 7 (7 April 2004)
Received 14 October 2003
Published 18 March 2004
Peter E Andersen et al 2004 Phys. Med. Biol. 49 1307
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