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Improved method of in vivo respiratory-gated micro-CT imaging

Erin B Walters, Kunal Panda, James A Bankson, Ellana Brown and Dianna D Cody

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The presence of motion artifacts is a typical problem in thoracic imaging. However, synchronizing the respiratory cycle with computed tomography (CT) image acquisition can reduce these artifacts. We currently employ a method of in vivo respiratory-gated micro-CT imaging for small laboratory animals (mice). This procedure involves the use of a ventilator that controls the respiratory cycle of the animal and provides a digital output signal that is used to trigger data acquisition. After inspection of the default respiratory trigger timing, we hypothesized that image quality could be improved by moving the data-acquisition window to a portion of the cycle with less respiratory motion. For this reason, we developed a simple delay circuit to adjust the timing of the ventilator signal that initiates micro-CT data acquisition. This delay circuit decreases motion artifacts and substantially improves image quality.


PACS

87.59.bd Computed radiography

87.19.X- Diseases

87.19.U- Hemodynamics

87.57.C- Image quality

Subjects

Biological physics

Medical physics

Dates

Issue 17 (7 September 2004)

Received 28 May 2004

Published 20 August 2004



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