M Nagel et al 2003 Phys. Med. Biol. 48 3625 doi:10.1088/0031-9155/48/22/001
M Nagel, F Richter, P Haring-Bolívar and H Kurz
Show affiliationsWe report on a novel resonant THz sensor for the label-free analysis of DNA molecules. The sensor allows the direct detection of DNA-probe molecules at functionalized electrodes via hybridization. Subsequent time resolved photoconductive sampling of the THz transmission identifies the binding state between probe and target DNA. Integrating neighbouring sensors on a chip, this technique can be extended to a parallel analysis of multiple DNA sequences. A clearly readable sensor response is obtained with less then 40 fmol of 20-mer single-stranded DNA molecules, indicating at least a sevenfold sensitivity increase compared to previous approaches.
87.80.-y Biophysical techniques (research methods)
07.57.-c Infrared, submillimeter wave, microwave and radiowave instruments and equipment
87.15.Cc Folding: thermodynamics, statistical mechanics, models, and pathways
87.15.B- Structure of biomolecules
Issue 22 (21 November 2003)
Received 2 June 2003
Published 24 October 2003
M Nagel et al 2003 Phys. Med. Biol. 48 3625
Marco Krohn and Michael Flohr JHEP01(2003)020
G S Buller and R J Collins 2010 Meas. Sci. Technol. 21 012002
Alan D Rendall 2004 Class. Quantum Grav. 21 S295
Yasusada Nambu and Yohei Araki 2006 Class. Quantum Grav. 23 511
A L C Ferreira and S K Mendiratta 1993 J. Phys. A: Math. Gen. 26 L145
J-R Chazottes et al 2005 Nonlinearity 18 2341
K. Mougin and H. Haidara 2003 Europhys. Lett. 61 660
Tomaž Prosen 2008 New J. Phys. 10 043026
R K Millard 2002 Physiol. Meas. 23 N1